张春阳

发布时间:2017年06月25日 23:45 点击: 来源:


基本资料

职称:  

教授  

专业:  

分析化学  

博(硕)导:  

博导  

最终学历:  

博士  

联系电话:  

0531-86186033  

电子邮件:  

cyzhang@sdnu.edu.cn  

简历及研究领域

个人简介:

张春阳,博士,教授,博士生导师,国务院政府特殊津贴专家。1999年在北京大学获博士学位,随后在清华大学完成博士后研究。2001年赴美,先后在埃默里大学、约翰霍普金斯大学和纽约城市大学工作。2009年回国加入中国科学院深圳先进技术研究院,现为山东师范大学化学化工与材料科学学院院长。2011年入选中国科学院“百人计划”, 2013年获国家杰出青年科学基金, 2014年入选深圳市“鹏城学者”特聘教授和广东省"南粤百杰"杰出人才工程, 2015年入选山东省“泰山学者”优势特色学科领军人才和科技部创新人才推进计划, 2017年入选国家“万人计划”科技创新领军人才。荣获山东省富民兴鲁劳动奖章和“山东省优秀科技工作者”称号。主要研究方向为单分子检测与成像及其临床应用研究。文章发表在Nature MaterialsJournal of the American Chemical SocietyAngewandte Chemie International EditionAnalytical Chemistry等国际有影响力杂志,并被ScienceNatureNature MaterialsAnalytical ChemistryScience Daily等国际权威期刊及媒体广泛报道和评论。

代表性论文

1.‍‍Yan Zhang, Wen-jing Xu, Ya-ping Zeng, Chun-yang Zhang*, Sensitive Detection of DNA Methyltransferase Activity by Transcription-Mediated Duplex-Specific  

Nuclease-Assisted Cyclic Signal Amplification, Chemical Communications, 2015, 51, 13968-13971.  

2.Yan Zhang, Jiao Liu, Chun-yang Zhang*, Real-Time Monitoring of Small Biological Molecules by Ligation-Mediated Polymerase Chain Reaction, Chemical  

Communications, 2015, 51, 12270-12273.  

3.Li-juan Wang, Yong Yang, Chun-yang Zhang*, Phosphorylation-Directed Assembly of Single Quantum Dot-Based Nanosensor for Protein Kinase Assay,  

Analytical Chemistry, 2015, 87, 4696-4703.  

4.Qinfeng Xu,Yihong Zhang, Chun-yang Zhang*, A Triple-Color Fluorescent Probe for Multiple Nuclease Assays,Chemical Communications, 2015, 51, 9121-9124.  

5.Guichi Zhu, Kun Yang, Chun-yang Zhang*, Single Quantum Dot-Based Biosensor for Telomerase Assay, Chemical Communications, 2015, 51, 6808-6811.  

6.Qinfeng Xu,Yan Zhang, Chun-yang Zhang*, A Universal Sensing Platform Based on the Repair Ligation-Mediated Light-Producing DNA Machine, Chemical  

Communications, 2015, 51, 5652-5655.  

7.Si-qiang Huang, Juan Hu, Guichi Zhu, Chun-yang Zhang*, Sensitive detection of point mutation using exponential strand displacement amplification-based surface  

enhanced Raman spectroscopy, Biosensors and Bioelectronics, 2015, 65, 191-197.  

8.Yong Yang, Chun-yang Zhang*, Visualizing and Quantifying Protein PolySUMOylation at the Single-Molecule Level, Analytical Chemistry, 2014, 86, 967-972.  

9.Fei Ma, Yong Yang, Chun-yang Zhang*, Ultrasensitive Detection of Transcription Factors Using Transcription-mediated Isothermally Exponential Amplification-  

Induced Chemiluminescence,Analytical Chemistry, 2014, 86, 6006-6011.  

10.Li-rong Zhang, Guichi Zhu, Chun-yang Zhang*, Homogeneous and Label-Free Detection of MicroRNAs Using Bifunctional Strand Displacement Amplification-  

Mediated Hyperbranched Rolling Circle Amplification, Analytical Chemistry, 2014, 86, 6703-6709.  

11.Jiao Du, Qinfeng Xu, Xiaoquan Lu*, Chun-yang Zhang*, A Label-Free Bioluminescent Sensor for Real-Time Monitoring Polynucleotide Kinase Activity,  

Analytical Chemistry, 2014, 86, 8481-8488.  

12.Guichi Zhu, Li Liang, Chun-yang Zhang*, A Quencher-free Fluorescent Method for Homogeneously Sensitive Detection of MicroRNAs in Human Lung Tissues, Analytical Chemistry, 2014, 86, 11410-11416.  

13.Guichi Zhu, Ying Li, Chun-yang Zhang*, Simultaneous detection of mercury (II) and silver (I) ions with picomolar sensitivity, Chemical Communications,  

2014, 50, 572-574.  

14.Yan Zhang, Li-juan Wang, Chun-yang Zhang*, Highly sensitive detection of telomerase using telomeres-triggered isothermal exponential amplification- based  

DNAzyme biosensor, Chemical Communications, 2014, 50, 1909-1911.  

15.Wei Tang, Guichi Zhu, Chun-yang Zhang*, Sensitive detection of polynucleotide kinase using rolling circle amplification-induced chemiluminescence, Chemical  

Communications, 2014, 50, 4733-4735.  

16.Ya-ping Zeng, Guichi Zhu, Xiao-yun Yang, Jun Cao, Zhi-liang Jing, Chun-yang Zhang*, A quantum dot-based microRNA nanosensor for point mutation assay,  

Chemical Communications, 2014, 50,7160-7162.  

17.Qinfeng Xu, Chun-yang Zhang*, Riboadenosine-substituted DNA probes for self-illuminating real-time monitoring exonuclease III activity and exonuclease III-  

assisted target recycling, Chemical Communications, 2014, 50, 8047-8049.  

18.Li-ping Ye, Juan Hu, Li Liang, Chun-yang Zhang*, Surface-enhanced Raman spectroscopy for simultaneously sensitive detection of multiple microRNAs in lung  

cancer cells, Chemical Communications, 2014, 50, 11883-11886.  

19.Juan Hu, Chun-yang Zhang*, Multiplex Detection of Lung Cancer Cells at the Single-Molecule Level, Chemical Communications, 2014, 50, 13581-13584.  

20.Li-juan Wang, Yan Zhang, Chun-yang Zhang*, A Target-Triggered Exponential Amplification-Based DNAzyme Biosensor for Ultrasensitive Detection of Folate  

Receptors, Chemical Communications, 2014, 50, 15393-15396.  

21.Lin-fei Zhang,Juan Zhou, Chun-yang Zhang*, pH-Controlled growth of ultrathin iron vanadium oxide (FeV3O8) nanoplatelets with high visible-light photo-  

catalytic activity, Journal of Materials Chemistry A, 2014, 2 (36), 14903-14907.  

22.Ying Li, Wei Tang, Li-rong Zhang, Chun-yang Zhang*, FMRP regulates miR196a-mediated repression of HOXB8 via interaction with AGO2 MID domain,  

Molecular BioSystems, 2014, 10 (7), 1757-1764.  

23.Lin-fei Zhang, Chun-yang Zhang*, Multifunctional Co0.85Se/Graphene Hybrid Nanosheets: Controlled Synthesis and Enhanced Performances for Oxygen  

Reduction Reaction and Decomposition of Hydrazine Hydrate, Nanoscale, 2014, 6, 1782 - 1789.  

24.Juan Zhou, Qiangxin Wang, Chun-yang Zhang*, Liposome-Quantum Dot Complexes Enable Multiplexed Detection of Attomolar DNAs without Target  

Amplification ,Journal of the American Chemical Society, 2013, 135, 2056-2059.  

25.Yong Yang, Chun-yang Zhang*, Simultaneous Measurement of SUMOylation via SNAP/CLIP-Tag-Mediated Translation at Single-Molecule Level, Angewandte Chemie International Edition, 2013, 52, 691-694.  

26.Juan Hu, Chun-yang Zhang*, Simple and Accurate Quantification of Quantum Yield at the Single-Molecule/Particle Level, Analytical Chemistry, 2013, 85, 2000-2004.  

27.Anping Cao, Chun-yang Zhang*, Real-Time Detection of Transcription Factors Using Target-Converted Helicase-Dependent Amplification Assay with Zero-  

Background Signal, Analytical Chemistry, 2013, 85, 2543-2547.  

28.Ya-ping Zeng, Juan Hu, Yi Long, Chun-yang Zhang*, Sensitive Detection of DNA Methyltransferase Using Hairpin Probe-Based Primer Generation Rolling  

Circle Amplification-Induced Chemiluminescence, Analytical Chemistry, 2013, 85, 6143-6150.  

29.Qinfeng Xu, Guichi Zhu, Chun-yang Zhang*, Homogeneous Bioluminescence Detection of Biomolecules Using Target-triggered Hybridization Chain Reaction-  

Mediated Ligation without Luciferase label, Analytical Chemistry, 2013, 85, 6915-6921.  

30.Ying Li, Li liang, Chun-yang Zhang*, Isothermally Sensitive Detection ofSerum Circulating miRNAs for Lung Cancer Diagnosis, Analytical Chemistry,  

2013, 85, 11174-11179.  

31.Li-juan Wang, Yan Zhang, Chun-yang Zhang*, Ultrasensitive Detection of Telomerase Activity at the Single-Cell Level, Analytical Chemistry, 2013, 85, 11509-11517.  

32.Juan Zhou, Yong Yang, Chun-yang Zhang*, A Low-Temperature Solid-Phase Method to Synthesize Highly Fluorescent Carbon Nitride Dots with Tunable  

Emission, Chemical Communications, 2013, 49 (77), 8605-8607.  

33.Jun-jie Hao, Juan Zhou, Chun-yang Zhang*, Tri-n-octylphosphine-Assisted Successive Ionic Layer Adsorption and Reaction Method to Synthesize Multilayered  

Core/Shell CdSe/ZnS Quantum Dots with Extremely High Quantum Yield, Chemical Communications, 2013, 49 (56), 6346-6348.  

34.Lin-fei Zhang, Chun-yang Zhang*, Controlled Growth of Concave Gold Nanobars with High Surface-Enhanced Raman-Scattering and Excellent Catalytic  

Activities, Nanoscale, 2013,5, 5794-5800.  

35.Lin-fei Zhang, Chun-yang Zhang*, Dodecahedral Au@Pd Nanocrystals with High-Index Facets and Excellent Electrocatalytic Activity and Highly Efficient  

Surface-Enhanced Raman Scattering Enhancement, Nanoscale, 2013, 5, 6074-6080.  

36.Guichi Zhu, Kun Yang, Chun-yang Zhang*, Sensitive detection of methylated DNA using the short linear quencher-fluorophore probe and two-stage isothermal  

amplification assay, Biosensors and Bioelectronics, 2013, 49, 170-175.  

37.Qinfeng Xu, Anping Cao, Ling-fei Zhang, Chun-yang Zhang*, Rapid and Label-free Monitoring of Exonuclease III-Assisted Target Recycling Amplification,  

Analytical Chemistry, 2012, 84, 10845-10851.  

38.Yan Zhang, Juan Hu, Chun-yang Zhang*, Sensitive Detection of Transcription Factors by Isothermal Exponential Amplification-Based Colorimetric Assay,  

Analytical Chemistry, 2012, 84, 9544-9549.  

39.Yi Long, Lingfei Zhang, Yan Zhang, Chun-yang Zhang*, Single QuantumDot-Based Nanosensor for Renin Assay,Analytical Chemistry, 2012, 84, 8846-8852.  

40.Guolei Wang, Chun-yang Zhang*, Sensitive Detection of MicroRNAswith Hairpin Probe-Based Circular Exponential Amplification Assay, Analytical Chemisty, 2012, 84,7037-7042.  

41.Anping Cao, Chun-yang Zhang*, Sensitive and Label-free DNAMethylation Detection by Ligation-Mediated Hyperbranched Rolling CircleAmplification,  

Analytical Chemistry,2012, 84, 6199–6205.  

42.Ying Li, Chun-yang Zhang*, Analysis of miRNA-Induced Silencing Complex-Involved miRNA-Target Recognition by Single-molecule Fluorescence Resonance  

Energy Transfer, Analytical Chemistry, 2012, 84, 5097–5102.  

43.Yong Yang, Chun-yang Zhang*, Sensitive Detection of IntracellularSumoylation via SNAP Tag-Mediated Translation and RNA Polymerase-  

BasedAmplification, AnalyticalChemistry, 2012, 84, 1229–1234.  

44.Zhen-zhu Zhang, Chun-yang Zhang*, Highly Sensitive Detection of Proteinwith Aptamer-Based Target-Triggering Two-Stage Amplification,  

Analytical Chemistry, 2012, 84, 1623–1629.  

45.Yan Zhang, Chun-yang Zhang*, Sensitive Detection of microRNA withIsothermal Amplification and a Single-Quantum-Dot-Based Nanosensor,  

Analytical Chemistry, 2012, 84, 224–231.  

46.Juan Hu, Chun-yang Zhang*, Single base extension reaction-based surfaceenhanced Raman spectroscopy for DNA methylation assay, Biosensors and  

Bioelectronics, 2012, 31, 451-457.  

47.Kun Yang, Chun-yang Zhang*, Simple Detection of Nucleic Acids with aSingle-walled Carbon-nanotube-based Electrochemical Biosensor, Biosensors and  

Bioelectronics, 2011,28, 257-262.  

48.Qiangxin Wang, Chun-yang Zhang*, Oriented Synthesis of One-dimensionalPolypyrrole Molecule Chains in a metal-organic framework, Macromolecular Rapid Communications, 2011, 32, 1610-1614.  

49.Fangming Zhan, Chun-yang Zhang*, Bifunctional nanoparticles withsuperparamagnetic and luminescence properties, Journal of Material Chemistry,2011, 21,4765-4767.  

50.Chun-yang Zhang*, Juan Hu, Single quantum dot-based nanosensor formultiple DNA detection. Analytical Chemistry, 2010, 82, 1921-7.  

51.Juan Hu, Chun-yang Zhang*,Sensitive Detection of Nucleic Acids with Rolling Circle Amplification andSurface-Enhanced Raman Scattering Spectroscopy,  

Analytical Chemistry,2010, 82, 8991–8997.  

52.Kun Yang, Chun-yang Zhang*,Improved Sensitivity for the Electrochemical Biosensor with an Adjunct Probe, Analytical Chemistry, 2010, 82, 9500-9505.  

53.Chun-yang Zhang, Lawrence W.Johnson, Single quantum-dot-based aptameric nanosensor for cocaine, Analytical Chemistry, 2009, 81, 3051-3055.  

54.Chun-yang Zhang, Lawrence W. Johnson, Simple and AccurateQuantification of Quantum Dots via Single-particle Counting, Journal of the American Chemical Society,2008, 130, 3750-3751.  

55.Chun-yang Zhang, Lawrence W. Johnson, Microfluidic control offluorescence resonance energy transfer: breaking the FRET limit, Angewandte Chemie  

International Edition, 2007, 46, 3482-3485.  

56.Chun-yang Zhang, Lawrence W. Johnson, Quantifying RNA-peptideinteraction by single-quantum-dot-based nanosensor: an approach for drugscreening,  

Analytical Chemistry, 2007, 79, 7775-7781.  

57.Chun-yang Zhang, Lawrence W. Johnson, Quantum-dot-based Nanosensor forRRE IIB RNA-Rev Peptide Interaction Assay, Journal of the American  

Chemical Society, 2006, 128,5324-5325.  

58.Chun-yang Zhang, Lawrence W. Johnson, Quantum-dot-based FluorescenceResonance Energy Transfer with Improved FRET Efficiency in Capillary Flows,  

Analytical Chemistry, 2006, 78, 5532-5537.  

59.Amit Agrawal,Chun-yang Zhang, Tyler Byassee, Ralph A. Tripp,Shuming Nie, Counting Single Native Biomolecules and Intact Viruses withColor-Coded  

Nanoparticles, Analytical Chemistry, 2006, 78, 1061-1070.  

60.Tza-Huei Wang, Yahui Peng, Chun-yang Zhang, Pak Kin Wong, Chih-Ming Ho,Single-molecule tracing on a fluidic microchip for quantitative detection  

oflow-abundance nucleic acids,Journal of the American Chemical Society, 2005, 127, 5354-5359.  

61.Chun-yangZhang, HsinChin Yeh, Marcos T. Kuroki, Tzahuei Wang, Single-quantum-dot-based DNA nonosensor,Nature Materials, 2005, 4, 826-831  

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