王昕

职称：

讲师

专业：

分析化学

博（硕）导：

硕导

最终学历：

博士研究生

联系电话：

18766177362

电子邮件：

xinwang@sdnu.edu.cn

简历及研究领域

个人简介：

学习工作经历：

2020年6月于山东师范大学获理学博士学位，2020年9月至今于山东师范大学化学化工与材料科学学院工作。主讲课程：《仪器分析化学实验》(本科必修课)、《分析化学实验》(本科必修课)。

研究领域：

致力于抑郁症相关生物标志物的光学成像分析，探究抑郁症分子机制及诊疗一体化试剂的开发。相关研究成果在 J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Anal. Chem.、Chem. Sci.等国际重要学术期刊上发表 SCI 论文共 36 篇，其中共同第一作者/通讯作者论文 11 篇，已授权国家发明专利 7项。目前主持在研国家自然科学基金青年基金、山东省自然科学基金优秀青年基金、山东省自然科学基金青年基金各1项。

招生信息：

每年在材料与化工专业招收专硕1-2名。

代表性论文

(1) Xin Wang; Ping Li,* Qi Ding; Chuanchen Wu; Wen Zhang; Bo Tang*. Observation of Acetylcholinesterase in Stress-induced Depression Phenotypes by Two-photon Fluorescence Imaging in the Mouse Brain. J. Am. Chem. Soc., 2019, 141, 2061-2068.

(2) Xin Wang, Ping Li,* Qi Ding, Chuanchen Wu, Wen Zhang, and Bo Tang*. Illuminating the Function of the Hydroxyl Radical in the Brains of Mice with Depression Phenotypes by Two‐Photon Fluorescence Imaging. Angew. Chem. Int. Ed., 2019, 58, 4674-4678.

(3) Qi Ding,† Ying Tian,† Xin Wang,* Ping Li,* Di Su, Chuanchen Wu, Wen Zhang, and Bo Tang*. Oxidative Damage of Tryptophan Hydroxylase2 Mediated by Peroxisomal Superoxide Anion Radical in Brains of Mouse with Depression. J. Am. Chem. Soc., 2020, 142, 20735–20743.

(4) Di Su, Ran Zhang, Xin Wang,* Qi Ding, Feida Che, Zhenzhen Liu, Jingwen Xu, Yuying Zhao, Kunqian Ji, WeiWu,* Chuanzhu Yan,* Ping Li,* and Bo Tang.* Shedding Light on Lysosomal Malondialdehyde Affecting Vitamin B12 Transport during Cerebral Ischemia/Reperfusion Injury. J. Am. Chem. Soc. 2023, 145, 41, 22609–22619

(5) Xin Wang‡, Feida Che‡, Xin Zhang, Ping Li*, Wen Zhang, and Bo Tang*, Tracing Superoxide Anion in Serotonergic Neurons of Living Mouse Brains with Depression by Small-Molecule Fluorescence Probes. Anal. Chem. 2023, 95, 42, 15614–15620

(6) Xin Wang,‡ Di Su,‡ Chunyu Liu, Ping Li*, Ran Zhang, Wen Zhang, Wei Zhang, and Bo Tang* A Janus-faced Fluorescence Imaging Agent for Malondialdehyde and Formaldehyde in Brains. Anal. Chem. 2022, 94, 43, 14965–14973

(7) Xin Wang,‡ Ruiyuan Wang,‡ Qi Ding, Wei Wu,* Feida Che, Ping Li,* Wen Zhang, Wei Zhang, Zhenzhen Liu, and Bo Tang.* Hypochlorous Acid-Activated Multifunctional Fluorescence Platform for Depression Therapy and Antidepressant Efficacy Evaluation. Anal. Chem., 2022, 94, 27, 9811–9818.

(8) Xin Wang,‡ Qi Ding,‡ Ying Tian, Wei Wu,* Feida Che, Ping Li,* Wen Zhang, Wei Zhang and Bo Tang*. In situ fluorescence imaging reveals that mitochondrial H2O2 mediates lysosomal dysfunction in depression. Chem. Commun., 2022, 58, 6320–6323.

(9) Xin Wang,† Xiaoyi Bai,† Di Su, Yandi Zhang, Ping Li,* Shuyi Lu, Yulin Gong, Wen Zhang, and Bo Tang*. Simultaneous Fluorescence Imaging Reveals NMethylDaspartic Acid Receptor Dependent Zn²⁺/H⁺ Flux in the Brains of Mice with Depression. Anal. Chem., 2020, 92, 4101−4107.

(10) Yandi Zhang,† Xin Wang,† Xiaoyi Bai, Ping Li,* Di Su, Wen Zhang, Wei Zhang, and Bo Tang*. Highly Specific Cys Fluorescence Probe for Living Mouse Brain Imaging via Evading Reaction with Other Biothiols. Anal. Chem., 2019, 91, 8591-8594.

研究课题

活体小鼠脑部生物活性分子的原位荧光成像研究 （50万）

山东省自然科学基金优秀青年基金（2024.01至2026.12）

抑郁症小鼠脑部5-羟色胺转运体的原位比率荧光成像研究 （30万）

国家自然科学基金青年基金（2024-01至2026-12）

抑郁小鼠脑内线粒体 ROS 及相关蛋白的荧光成像研究（15万）

山东省自然科学基金青年基金（2022.01至2024.12）