高晓南

职称：

副教授

专业：

物理化学

博（硕）导：

硕导

最终学历：

博士研究生

联系电话：

电子邮件：

Gaox@sdnu.edu.cn

简历及研究领域 纳米荧光探针

个人简介：

高晓南，2016年5月毕业于美国弗吉尼亚联邦大学获得博士学位，2016年10月至今于山东师范大学工作。主要从事纳米荧光探针在癌症的检测和治疗方面的相关研究工作。目前主持国家自然科学基金一项，山东省科技厅和教育厅项目各一项，参与国家自然科学基金面上项目以及海外合作研究基金项目等多项。

教学方面多年全英文授课，讲授《Introduction to Chemical Science》、《Chemical and Physical Properties of Matter》、《Professional English》、《Chemical Dynamics》四门课程，主持多项教学改革项目，2022年荣获山东省青年教师教学比赛省级二等奖。

本课题组每年招收两名物理化学方向研究生，欢迎邮件问询。

代表性论文

1. Guo Wenfei; Gao Xiaonan *; Zhang Qin; Hu Bo, Sun Jingping; Zhao Xingya; Xu Kehua; Tang Bo. Self-Assembly-Based Nanoprobes for the Simultaneous Detection and Downregulation of HSP90α mRNA to Enhance Photothermal Therapy. Anal. Chem. 2023, 95, 4682-4691.

2. Gao Xiaonan; Jia Zhikai; Cheng Yaoying; Ouyang Mingyi; Feng Lin; Wang Yuzhuo; Tang Bo; Xu Kehua. A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment. Chem. Common. 2022, 58, 12090-12093.

3. Gao Xiaonan; Hu Bo; Zhao Zengteng; Niu Tianrun; Liu Yifan; Xu Kehua; Tang Bo. Synthesis of Au–Se bonded nanoprobe for specific detection of thrombin in lung cancer cells. Sens. Actuators B Chem. 2022, 352, 130999.

4. Gao Xiaonan; Niu Tianrun; Xia Qinghua; Hu Bo; Zhao Zengteng; Feng Xinyi; Yang Jingqi; Tang Bo; Xu Kehua. Au–Se bonded nanoprobe for prostate specific antigen detection in serum. Anal. Chim. Acta 2022, 1210, 339852.

5. Zheng Aishan; Han Liu; Chuanhao Peng; Xiaonan Gao*; Kehua Xu; Bo Tang. A mitochondria-targeting near-infrared fluorescent probe for imaging hypochlorous acid in cells. Talanta 2021, 226, 122152.

6. Gao, Xiaonan; Li, Jia; Luan, Mingming; Li, Yanhua; Pan, Wei; Li, Na; Tang, Bo. Real time in situ monitoring cathepsin B and caspase-3 for intracellular apoptosis pathway study via Au-Se constructed nanoprobe. Biosen. & Bioelectron. 2020, 147: 0-111755.

7. Gao, Xiaonan; Guo, Wenfei; Jiang, Lulu; Hu, Bo; Liu, Xiaojun; Xu, Kehua; Tang, Bo. Simultaneous bioimaging of MMP-2 and MMP-7 via Au-Se constructed fluorescence nanoprobe. Sci. China Chem. 2020, 63, 135-140.

8. Gao Xiaonan; Zhao Congcong; Wei Keyan; Hu Bo; Chen Yuqin; Xu Kehua; Tang Bo. A differential study on oxidized/reduced ascorbic acid induced tumor cells’ apoptosis under hypoxia. Analyst, 2020, 145, 6363-6368.

9. Gao, Xiaonan; Wei, Keyan; Hu, Bo; Xu, Kehua; Tang, Bo. Ascorbic acid induced HepG2 cells’ apoptosis via intracellular reductive stress. Theranostics 2019, 9, 4233-4240.

10. Gao, Xiaonan; Fu, Ai Yun; Liu, Bo; Jin, Jun cheng; Dou, Long Tao; Chen, Li Xia. Unique topology analysis by ToposPro for a metal-organic framework with multiple coordination centers. Inorg. Chem. 2019, 58, 3099-3106.

11. Zhao, Yuehui; Wei, Keyan; Kong, Fanpeng; Gao, Xiaonan^*; Xu, Kehua; Tang, Bo.Dicyanoisophorone-based near-infrared fluorescent probe for detecting NAD(P)H in living cells and in vivo. Anal. Chem. 2019, 91, 1368-1374.

12. Gao Xiaonan; Jiang, Lulu; Hu, Bo; Kong, Fanpeng; Liu, Xiaojun; Xu, Kehua; Tang, Bo. Au-Se bond based nanoprobe for imaging MMP-2 in tumor cells under high thiols environment. Anal. Chem. 2018, 90, 4719-4724.

13. Li, Yanli^#; Gao, Xiaonan^#; Yu, Zhengze; Liu, Bo; Pan, Wei; Li, Na; Tang, Bo. Reversing multidrug resistance by multiple gene silencing for enhanced breast cancer chemotherapy. ACS Appl. Mater. Interfaces 2018, 10, 15461-15466.

14. Luan, Dongrui^#; Gao, Xiaonan^#; Kong, Fanpeng; Song, Xiaoxiao; Zheng, Aishan; Liu, Xiaojun; Xu, Kehua; Tang, Bo. Cyclic Regulation of Sulfilimine Bond in Peptides and NC1 Hexamers via HOBr/H₂Se Conjugated System. Anal. Chem. 2018, 90, 9523-9528.

15. Gao, Xiaonan; Guo, Wenfei; Ge, Lihong; Kong, Fanpeng; Xu, Kehua; Tang, Bo. Doubleratiometric fluorescence imaging of H2Se and O2˙− under hypoxia for exploring Na2SeO3-induced HepG2 cells' apoptosis. RSC Advan. 2018, 8, 40984-40988.

16. Gao, Xiaonan; Zhang, Cun Lan; Fu, Ai Yun. Crystal structure of di-μ2-aqua-tetraaqua-bis (4-(1H-1, 2, 4-triazol-1-yl) benzoato-κN) disodium (I) C18H24N6Na2O10 Z. Kristallogr. - New Cryst. Struct. 2018. 233, 965-966.

17. Hu, Bo; Kong, Fanpeng; Gao, Xiaonan; Jiang, Lulu; Li, Xiaofeng; Gao, Wen; Xu, Kehua; Tang, Bo. Avoiding thiol compound interference: a high-fidelity Au-Se bonding nanoplatform and its biological applications. Angew. Chem. Int. Ed. 2018, 57, 5306-5309.

研究课题

国家自然科学基金青年项目

定量指示活细胞内不同细胞器pH的比率纳米荧光探针的设计与合成

山东省科技厅博士基金项目

癌症诊疗一体化纳米荧光探针的设计合成及应用  

山东省高等学校科研计划项目

精确检测活细胞内不同细胞器pH的比率纳米荧光探针的设计合成

青年科研培育基金

设计合成比率纳米荧光探针用于活细胞内不同细胞器pH的精准检测

校级教学改革立项面上项目

普通化学全英文授课在国际联合培养创新性人才的改革与实践

教育部产学合作协同育人项目

VR技术在基础化学实验中的应用

荣誉称号

2022

山东省青年教师教学比赛省级二等奖