李璐

职称： 

教授 

专业： 

分析化学 

博(硕)导： 

博导 

最终学历： 

博士 

联系电话： 

15954911357 

电子邮件： 

lilu5252@163.com 

简历及研究领域

简介：

李璐，女，汉族，教授， 1983年6月生，2005年与2010年于山东大学分别获得学士学位和博士学位，2011年9月到山东师范大学工作至今，2017年晋升教授。目前主要从事生物分子的单细胞和单分子分析研究，在Chem. Sci., Anal. Chem., Chem. Commun.等杂志上发表SCI论文30余篇，其中以第一作者发表论文17篇，影响因子大于5的14篇，目前主持国家自然科学基金面上项目1项和山东省省属高校优秀青年科学家奖励基金1项，主持完成国家自然科学基金青年基金项目、教育部科学技术研究重点项目等多项国家级和省部级项目。

代表性论文

主要科研成果：

代表性论文：

1. Lu Li, Jie Feng, Haiyun Liu, Qingling Li, Lili Tong and Bo Tang*. Two-color imaging of microRNA with enzyme-free signal amplification via hybridization chain reactions in living cells. Chem. Sci.2016, 7, 1940-1945.

2. Haibin Si, Renjie Sheng, Qingling Li, Jie Feng, Lu Li* and Bo Tang*. Highly Sensitive Fluorescence Imaging of Zn²⁺ and Cu²⁺ in Living Cells with Signal Amplification based on Functional DNA SelfAssembly. Analytical Chemistry, 2018, 90, 8785–8792

3. Haibin Si, Lijuan Wang, Qingling Li, Xiaoxiao Li, Lu Li* and Bo Tang*. In-situ fluorescent monitoring of diagnosis and treatment: a versatile nanoprobe combining tumor targeting based on MUC1 and controllable DOX release by telomerase. Chem. Commun. 2018, 54, 8277--8280.

4. Yuanyuan Fan, Defang Dong, Qingling Li, Haibin Si, Haimeng Pei, Lu Li* and Bo Tang*. Fluorescent analysis of bioactive molecules in single cells based on microfluidic chips. Lab Chip, 2018, 18, 1151-1173.

5. Lu Li, Yuanyuan Fan, Qingling Li, Renjie Sheng, Haibin Si, Juan Fang, Lili Tong, and Bo Tang*. Simultaneous Single-Cell Analysis of Na⁺, K⁺, Ca²⁺, and Mg²⁺ in Neuron-Like PC-12 Cells in a Microfluidic System. Anal. Chem., 2017, 89(8): 4559–4565.

6. Qingling Li, Peilin Chen, Yuanyuan Fan, Xu Wang, Kehua Xu, Lu Li* and Bo Tang*. Multicolor Fluorescence Detection-Based Microfluidic Device for Single-Cell Metabolomics: Simultaneous Quantitation of Multiple Small Molecules in Primary Liver Cells. Anal. Chem.2016, 88, 8610−8616.

7. Lu Li, Qingling Li, Peilin Chen, Zhongyi Li, Zhenzhen Chen, and Bo Tang*. Consecutive Gated Injection-Based Microchip Electrophoresis for Simultaneous Quantitation of Superoxide Anion and Nitric Oxide in Single PC-12 Cells. Anal. Chem.2016, 88, 930-936.

8. Lu Li, Ping Li, Juan Fang, Qingling Li, Haibin Xiao, Hui Zhou, and Bo Tang*. Simultaneous Quantitation of Na⁺ and K⁺ in Single Normal and Cancer Cells Using a New Near-Infrared Fluorescent Probe. Anal. Chem.2015, 87, 6057-6063.

9. Lu Li, Jie Feng, Yuanyuan Fan, and Bo Tang*. Simultaneous Imaging of Zn²⁺ and Cu²⁺ in Living Cells Based on DNAzyme Modified Gold Nanoparticle. Anal. Chem. 2015, 87, 4829–4835.

10. Lu Li, Qian Wang, Jie Feng, Lili Tong, and Bo Tang Highly Sensitive and Homogeneous Detection of Membrane Protein on a Single Living Cell by Aptamer and Nicking Enzyme Assisted Signal Amplification Based on Microfluidic Droplets. Anal. Chem.2014, 86, 5101-5107.

11. Lu Li, Feifei Gao, Jian Ye, Zhenzhen Chen, Qingling Li, Wen Gao, Lifei Ji, Ruirui Zhang, and Bo Tang*, A FRET-based Bio-friendly Apo-GOx modified Gold Nanoprobe for Specific and Sensitive Glucose Sensing and Cellular Imaging, Anal. Chem. 2013, 85, 9721-9727.

12. Haiyun Liu^#, Lu Li^# (共同第一), Qian Wang, Lili Duan, and Bo Tang*. Graphene Fluorescence Switch-Based Cooperative Amplification: A Sensitive and Accurate Method to Detection MicroRNA. Anal. Chem., 2014, 86, 5487-5493.

13. Haiyun Liu^#, Lu Li^# (共同第一), Lili Duan, Xu Wang, Yanxia Xie, Lili Tong, Qian Wang, and Bo Tang*, High Specific and Ultrasensitive Isothermal Detection of MicroRNA by Padlock Probe-Based Exponential Rolling Circle Amplification, Anal. Chem. 2013, 85, 7941-7947.

14. Lu Li, Xiuli Wang, Qingling Li, Pengyuan Liu, Kehua Xu, Hao Chen* and Bo Tang*. An Accurate Mass Spectrometric Approach for the Simultaneous Comparison of GSH, Cys, and Hcy in L02 Cells and HepG2 Cells using New NPSP Isotope Probes. Chem. Commun.2015, 51, 11317-11320.

15. Ruirui Zhang^#, Lu Li^# (共同第一), Jie Feng, Lili Tong, Qian Wang, and Bo Tang*. Versatile Triggered Release of Multiple Molecules from Cyclodextrin Modified Gold Gated Mesoporous Silica Nanocontainers. ACS Appl. Mater. Interfaces, 2014, 6, 9932-9936.

16. Lu Li, Xianwei Wang, Xiaoli Zhang, Jinxing Wang,*, Wenrui Jin*, Single-cell multiple gene expression analysis based on single-molecule-detection microarray assay for multi-DNA determination, Analytica Chimica Acta. 2015, 854, 122–128.

17. Lu Li, Liping Shen, Xiaoqian Zhang, Lingling Shui, Benhui Sui, Xiaoli Zhang, Xiaofan Zhao, Wenrui Jin * Multiplexed optical coding nanobeads and their application in single molecule counting analysis for multiple gene expression analysis, Analytica Chimica Acta.2015, 886, 123–132.

国家自然科学基金面上项目

基于信号放大的肺癌、肝癌细胞内多种活性分子同时高灵敏荧光成像新方法研究（21675104、2017.01-2020.12） 

山东省自然科学基金省属高校优秀青年人才联合基金 

肿瘤细胞内多种生物分子的同时单细胞高灵敏荧光成像和定量研究（ZR2016JL008、2016.11-2019.11） 

高等学校博士学科点专项科研基金（新教师类） 

靶向活细胞线粒体的功能纳米荧光探针对电子传递链过程中活性氧变化的相关信息研究（20123704120006、2013.01-2015.12）

国家自然科学基金青年基金 

肝癌细胞内基因和蛋白类肿瘤标志物的单细胞、单分子荧光检测（21205074、2012.10-2015.12） 

教育部科技研究重点项目 

单细胞内肿瘤标志物的单分子荧光分析（212102、2012.10-2014.12）